U.S. Bancorp is an American multinational bank holding company headquartered in Minneapolis, Minnesota, operating primarily through its subsidiary U.S. Bank National Association. It is the seventh-largest bank in the United States, the largest in the Midwest, and is designated a systemically important financial institution. The company provides banking, investment, mortgage, trust, wealth management and payment services to individuals, businesses, government entities and other financial institutions, holding roughly $692 billion in assets as of 31 December 2025. It is also one of the largest US asset custodians, with more than $11.7 trillion under administration, and in 2026 expanded its capital markets business by acquiring institutional broker-dealer BTIG.